Ventilation Question

[Emperor Zurg]

Since your are determined to cut holes in your house, wherever the fresh air is coming in, I'd put the exhaust on the opposite side of the room for cross flow. Otherwise you'll have dead spots. Idk what HVAC is on your drawing. I figure it must be the register blowing air into the room? I tend to get fancy on things like that though so if air normally is drawn from under the door but when the HVAC kicks on it comes from that vent I'd probably have to put 3 or 4 vents in and have the 2 furthest from the door running normally but then automatically kick it over to 1 or 2 vents near the door only when the HVAC comes on. Or maybe run all of them when the HVAC comes on, depending on how much air it shoves into the room. But then I probably wouldn't ever put a smoking room in my house anyway.